PandemieGrippaleV1, Main, Exploration, bibRecord, 001063

Mortality Associated With Seasonal and Pandemic Influenza and Respiratory Syncytial Virus Among Children <5 Years of Age in a High HIV Prevalence Setting-South Africa, 1998-2009

Identifieur interne : 001063 ( Main/Exploration ); précédent : 001062; suivant : 001064

Mortality Associated With Seasonal and Pandemic Influenza and Respiratory Syncytial Virus Among Children <5 Years of Age in a High HIV Prevalence Setting-South Africa, 1998-2009

Auteurs : Stefano Tempia [États-Unis, Afrique du Sud] ; Sibongile Walaza [Afrique du Sud] ; Cecile Viboud [États-Unis] ; Adam L. Cohen [États-Unis, Afrique du Sud] ; Shabir A. Madhi [Afrique du Sud, États-Unis] ; Marietjie Venter [Afrique du Sud] ; Johanna M. Mcanerney [Afrique du Sud] ; Cheryl Cohen [Afrique du Sud]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2014.

RBID : Pascal:14-0137128

Descripteurs français

Pascal (Inist)
- Grippe, SIDA, Mortalité, Variation saisonnière, Voie respiratoire, Virus respiratoire syncytial humain, Enfant, Virus immunodéficience humaine, Age, Prévalence, Afrique du Sud, Pronostic, Pathologie de l'appareil respiratoire, Pandémie.
Wicri :
- geographic : Afrique du Sud.
- topic : Mortalité, Enfant.

English descriptors

KwdEn :
- AIDS, Age, Child, Human immunodeficiency virus, Human respiratory syncytial virus, Influenza, Mortality, Prevalence, Prognosis, Respiratory disease, Respiratory tract, Seasonal variation, South Africa.

Abstract

Background. There are few published data describing the mortality burden associated with influenza and respiratory syncytial virus (RSV) infection in children in low- and middle-income countries and particularly from Africa and settings with high prevalence of human immunodeficiency virus (HIV). Methods. We modeled the excess mortality attributable to influenza (seasonal and pandemic) and RSV infection by applying Poisson regression models to monthly all-respiratory and pneumonia and influenza deaths, using national influenza and RSV laboratory surveillance data as covariates. In addition, we estimated the seasonal influenza- and RSV-associated deaths among HIV-infected and -uninfected children using Poisson regression models that incorporated HIV prevalence and highly active antiretroviral therapy coverage as covariates. Results. In children <5 years of age, the mean annual numbers of seasonal influenza- and RSV-associated all-respiratory deaths were 452 (8 per 100 000 person-years [PY]) and 546 (10 per 100 000 PY), respectively. Infants <1 year of age experienced higher mortality rates compared with children 1-4 years of age for both influenza (22 vs 5 per 100 000 PY) and RSV (35 vs 4 per 100 000 PY). HIV-infected compared with HIV-uninfected children <5 years of age were at increased risk of death associated with influenza (age-adjusted relative risk [aRR], 11.5; 95% confidence interval [CI], 9.6-12.6) and RSV (aRR, 8.1; 95% CI, 6.9-9.3) infection. In 2009, we estimated 549 (11 per 100 000 PY) all-respiratory influenza A(H1N1)pdm09-associated deaths among children aged <5 years. Conclusions. Our findings support increased research efforts to guide and prioritize interventions such as influenza vaccination and HIV prevention in low- and middle-income countries with high HIV prevalence such as South Africa.

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Age</term>
<term>Child</term>
<term>Human immunodeficiency virus</term>
<term>Human respiratory syncytial virus</term>
<term>Influenza</term>
<term>Mortality</term>
<term>Prevalence</term>
<term>Prognosis</term>
<term>Respiratory disease</term>
<term>Respiratory tract</term>
<term>Seasonal variation</term>
<term>South Africa</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Grippe</term>
<term>SIDA</term>
<term>Mortalité</term>
<term>Variation saisonnière</term>
<term>Voie respiratoire</term>
<term>Virus respiratoire syncytial humain</term>
<term>Enfant</term>
<term>Virus immunodéficience humaine</term>
<term>Age</term>
<term>Prévalence</term>
<term>Afrique du Sud</term>
<term>Pronostic</term>
<term>Pathologie de l'appareil respiratoire</term>
<term>Pandémie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
<term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. There are few published data describing the mortality burden associated with influenza and respiratory syncytial virus (RSV) infection in children in low- and middle-income countries and particularly from Africa and settings with high prevalence of human immunodeficiency virus (HIV). Methods. We modeled the excess mortality attributable to influenza (seasonal and pandemic) and RSV infection by applying Poisson regression models to monthly all-respiratory and pneumonia and influenza deaths, using national influenza and RSV laboratory surveillance data as covariates. In addition, we estimated the seasonal influenza- and RSV-associated deaths among HIV-infected and -uninfected children using Poisson regression models that incorporated HIV prevalence and highly active antiretroviral therapy coverage as covariates. Results. In children <5 years of age, the mean annual numbers of seasonal influenza- and RSV-associated all-respiratory deaths were 452 (8 per 100 000 person-years [PY]) and 546 (10 per 100 000 PY), respectively. Infants <1 year of age experienced higher mortality rates compared with children 1-4 years of age for both influenza (22 vs 5 per 100 000 PY) and RSV (35 vs 4 per 100 000 PY). HIV-infected compared with HIV-uninfected children <5 years of age were at increased risk of death associated with influenza (age-adjusted relative risk [aRR], 11.5; 95% confidence interval [CI], 9.6-12.6) and RSV (aRR, 8.1; 95% CI, 6.9-9.3) infection. In 2009, we estimated 549 (11 per 100 000 PY) all-respiratory influenza A(H1N1)pdm09-associated deaths among children aged <5 years. Conclusions. Our findings support increased research efforts to guide and prioritize interventions such as influenza vaccination and HIV prevention in low- and middle-income countries with high HIV prevalence such as South Africa.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>États-Unis</li>
</country>
<region><li>Gauteng</li>
<li>Géorgie (États-Unis)</li>
<li>Maryland</li>
</region>
<settlement><li>Johannesbourg</li>
</settlement>
<orgName><li>Université du Witwatersrand</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name>
</region>
<name sortKey="Cohen, Adam L" sort="Cohen, Adam L" uniqKey="Cohen A" first="Adam L." last="Cohen">Adam L. Cohen</name>
<name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A." last="Madhi">Shabir A. Madhi</name>
<name sortKey="Viboud, Cecile" sort="Viboud, Cecile" uniqKey="Viboud C" first="Cecile" last="Viboud">Cecile Viboud</name>
</country>
<country name="Afrique du Sud"><noRegion><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name>
</noRegion>
<name sortKey="Cohen, Adam L" sort="Cohen, Adam L" uniqKey="Cohen A" first="Adam L." last="Cohen">Adam L. Cohen</name>
<name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name>
<name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name>
<name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A." last="Madhi">Shabir A. Madhi</name>
<name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A." last="Madhi">Shabir A. Madhi</name>
<name sortKey="Mcanerney, Johanna M" sort="Mcanerney, Johanna M" uniqKey="Mcanerney J" first="Johanna M." last="Mcanerney">Johanna M. Mcanerney</name>
<name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name>
<name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name>
<name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name>
<name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name>
</country>
</tree>
</affiliations>
</record>

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Mortality Associated With Seasonal and Pandemic Influenza and Respiratory Syncytial Virus Among Children <5 Years of Age in a High HIV Prevalence Setting-South Africa, 1998-2009

Mortality Associated With Seasonal and Pandemic Influenza and Respiratory Syncytial Virus Among Children <5 Years of Age in a High HIV Prevalence Setting-South Africa, 1998-2009

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